Bone Marrow Transplant at World Best Hospitals in India

A large number of foreign patients now come to India for Live Related Organ Transplant Surgery like Kidney Transplants, Liver Transplants and Bone Marrow Transplants. Organ Transplantation is a very complex surgical specialty and requires very high degree of Clinical skills and Medical Technology and Infrastructure. India has now become the most preferred destination for organ transplant procedures. These include Liver, Kidney and Bone marrow transplant surgeries. .Not only the cost is low; the success rate of organ transplant in India is at par with the world's best success rate for organ transplant.
Since Organ Transplantation is a very complex surgical specialty and requires very high degree of Clinical skills and Medical Technology, and Indian surgeons and healthcare has proven its competence, there has been a great surge in the number of medical tourists coming to India for various organ transplants. The Infrastructure and technology used at these best organ transplant hospitals in India is the most sophisticated technology available in the world, which results in better patient recovery, higher success rate, low cost and convenience to the patient.

Bone Marrow Transplant
Stem cells produce red blood cells, white blood cells, and platelets. In some cases, stem cells in your bone marrow may not be functioning well or need to be destroyed to help treat a disease. If this happens, you will need new stem cells.
During this procedure, healthy stem cells are taken from a donor's:·         Bone marrow (bone marrow transplant or BMT)
·         Blood (peripheral blood stem cell or PBSC)


The stem cells will be injected into your vein. The new cells travel through the bloodstream to your bone cavities. It may take about a month for the donor stem cells in the bone marrow to begin to function fully. If the transplant is successful, new bone marrow cells will produce healthy red blood cells, white blood cells, and platelets.

Stem cell transplantation may be done using:·         Stem cells that were taken from your own bone marrow or blood and stored
·         Stem cells from a donor

How Bone Marrow Transplant would be donePrior to procedure the donor will be carefully tested to check for diseases. Both you and the donor will be tested to ensure that your tissues are compatible. In order for the transplant to be successful, certain markers, called HLS types, on the blood cells and bone marrow cells must match.

As the recipient, you will be given medicines to suppress your immune system. This is to prevent your body from rejecting the donor stem cells. In the weeks prior to the transplant, you may have to have:
·Chemotherapy
·Radiation therapy



This process is called "conditioning." It will rid the body of diseased cells and clear the bone marrow cavities for the new bone marrow.

If the stem cells will be from the donor's bone marrow (BMT), the doctor will clean an area of the donor's hip. A hollow needle and     syringe will be used to remove the bone marrow.The doctor will make several small punctures. This is to harvest enough bone marrow for the transplant (1-2 quarts). Lastly, the wounds will be covered with bandages.
If the stem cells will be from the donor's blood (PBSC), the doctor will stick a needle in the donor's large vein or veins in the arms. A machine will receive blood from the vein. This machine will spin the blood so that the stem cells are concentrated. The rest of the blood will be given back to the donor. The doctor will cover the puncture wounds with bandages. This procedure may require more than one blood donation. The donor may also be required to take pills that cause more stem cells from the bone marrow to go into the blood.
The donated stem cells will be filtered. Next, the doctor will administer the cells through a small, flexible tube, called a catheter, into one of your large veins.
Immediately after procedure the donor will recover quickly. You, the recipient, will be placed in isolation. This is to avoid infection until the new stem cells in the bone marrow begin to produce infection-fighting cells.

Recovery
The new bone marrow normally takes almost a year in order to function normally. During this period the patient is to be monitored closely to identify any infections or complications that may develop. The recovery process continues for several months or longer after discharging from the hospital, during which time the patient cannot return to work or many previously enjoyed activities.

MedWorld India Affiliated Hospitals in India the Leading Destination for Organ Transplant Surgery
·         Indian doctors are known all over the world for their skill and knowledge and have the experience of studying and working at the best hospitals in the world.

·         India's leading liver transplant centre conducts perhaps the world's highest number of liver transplants (16 to 18 every month)
·         The hospital has a special centre for liver diseases amongst children and liver transplants for children . Highly skilled surgical teams with vast experience and excellent track record of doing largest numbers of Live related donor kidney and liver transplants with survival rates comparable to world's best centers.
·         Most advanced Technology Infrastructure - Blood Bank with 24 hour apharesis facility, advanced laboratory and microbiology (infection control) support, advanced cardiology, DSA and interventionalradiology, portable and colour ultra-sonology, Liver Fibro-scan, 64 slice CT scanner, 3 T MRI, PET-CT and nephrology (including 24 hour dialysis and CVVHD) facilities. Organ Transplant Hospitals in India are now equipped with the latest and high end technology


For more information visit: http://www.medworldindia.com    
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Please scan and email your medical reports  to us at care@medworldindia.com and we shall get you a Free Medical Opinion from India’s Best Doctors.
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Types of Bone Marrow and Stem Cell Transplants. Autologous. Autologous transplant uses your own stem cells

Types of Bone Marrow Transplants

• Germ Cell (Testicular) Cancer
• Lymphomas
• Multiple myeloma, and related diseases. Occasionally, this type of transplant is used for treatment of leukemia.
• Leukemias and bone marrow or immune system failure diseases.
• Reduced intensity or "mini"-transplant refers to a type of allogeneic transplant in which the pre-transplant

chemotherapy and/or radiation (called conditioning, see below) is less than maximally intensive. This type of transplant depends heavily on the anti-tumor effect of the donor cells for its therapeutic effect, so it generally requires that the disease either be in remission or very slow growing at the time of transplant. The immediate side effects of a reduced intensity transplant are less than those associated with a standard transplant, making it possible to offer transplant to a wider variety of people, including those who might otherwise not be transplant candidates because of age or other illnesses.

What the Donor Experiences
If stem cells are collected by bone marrow harvest (much less likely), the donor will go to the operating room and while asleep under anesthesia, a needle will be inserted into either the hip or the breastbone to take out some bone marrow. After awakening, he/she may feel some pain where the needle was inserted.

Autologous (self-transplant): This is the simplest form of transplant, and involves collection of the patient's own cells, which are counted, analyzed, and then frozen for later use. This type of transplant is most commonly performed for

• Hodgkin Disease

Bloodless Transfusions: For patients requiring a bloodless stem cell transplantation, our transplant center specializes in doing what is known as Bloodless Autologous transplants where patients do not receive any allogenic blood or blood products after the stem cell reinfusion. The period of cytopenias is managed with growth factors & other drugs to prevent bleeding.

Syngeneic (identical twin transplant): An identical twin is an ideal donor because of the genetic identity between the donor and recipient. It is like using one's own cells, except that the cells are not damaged from prior exposure to chemotherapy, and the risk to tumor cell contamination is eliminated.

Allogeneic (donor transplant): For this form of transplant, the stem cells are collected from a relative (usually a sibling), or other donor (volunteer unrelated donor or umbilical cord blood), whose tissue type matches closely with that of the patient. The chances of a brother or sister being a suitable match are about 1 in 4. The chances of any other family member being a match are much less, so we usually do not recommend extended family typing. Allogeneic transplants are most commonly done for

In most cases, a donation is made using circulating stem cells (PBSC) collected by apheresis. First, the donor receives injections for a few days of a medication that causes stem cells to move out of the bone marrow and into the blood. For the stem cell collection, the donor is connected to a machine by a needle inserted in the vein (like for blood donation). Blood is taken from the vein, filtered by the machine to collect the stem cells, then returned back to the donor through a needle in the other arm. There is almost no need for a recovery time with this procedure.

A bone marrow transplant is a difficult procedure to go through. Usually the person receives high doses of chemotherapy and/or radiation to eliminate whatever bone marrow he/she has left to make room for the new marrow transplant. Once this is done, the new stem cells are put into the person intravenously, similar to a blood transfusion. The stem cells then find their way to the bone and start to grow and produce more cells (called engraftment).

Blood Cancer Treatment‎ : Bone marrow transplant procedure in India

How the Bone Marrow Functions

Bone marrow is the soft, spongy center of your bone where blood is produced. Marrow is filled with blood-producing cells, called stem cells, which develop into mature white blood cells, red blood cells or platelets. White blood cells of various kinds make up part of your immune system for fighting infections.Red blood cells are responsible for carrying oxygen throughout your body.Platelets clot your blood to prevent bleeding. Stem cells are constantly being produced by your bone marrow, and will develop into the types of cells your body needs.

Types of Bone Marrow Transplants

Most people who need to undergo a bone marrow transplant have cancer, such as leukemia or lymphoma. There are different types of bone marrow transplants. The type and severity of your disease determine what type of bone marrow transplant you will need.

Allogeneic Bone Marrow Transplants

An allogeneic bone marrow transplant involves receiving donor bone marrow or peripheral stem cells. This bone marrow transplant donor is genetically matched and can be related or unrelated to you. An autologous transplant involves receiving your own bone marrow or peripheral stem cells. A syngeneic bone marrow transplant involves receiving your identical twin's bone marrow or peripheral stem cells.

Allogeneic Transplants

An allogeneic bone marrow transplant involves receiving very high-doses of chemotherapy and/or radiation therapy, followed by the infusion of your donor's bone marrow or peripheral stem cells. The high-dose cancer fighting treatments are given to eliminate the cancer in your body. The infusion of the new marrow or peripheral stem cells during an allogeneic bone marrow transplant replaces the bone marrow destroyed by the chemotherapy and/or radiation therapy.

You may be a potential candidate for an allogeneic bone marrow transplant if you have leukemia, aplastic anemia, myelodysplasia, myelofibrosis, high-grade lymphoma or other types of cancers.

A non-myeloablative (“mini”) allogeneic bone marrow transplant involves receiving low-doses of chemotherapy and radiation therapy followed by the infusion of your donor's bone marrow or peripheral stem cells. The objective of the bone marrow transplant is to suppress your own bone marrow by receiving just enough chemotherapy and radiation therapy to allow your donor cells to engraft and grow within you. The hope is these donor cells will mount an immunologic attack against your underlying cancer, generating a response called the "graft-versus-leukemia" effect or “graftversus- cancer” effect.

You may be a potential candidate for a mini allogeneic transplant if you have a slow growing, indolent disorder, such as chronic leukemia, multiple myeloma, myelodysplasia, low-grade lymphoma, and in some cases, renal cell carcinoma. The mini allogeneic transplant is not appropriate, for example, if you have fast-growing acute leukemia.

Autologous Bone Marrow Transplants

An autologous bone marrow transplant involves receiving very high-dose chemotherapy followed by the infusion of your previously-collected peripheral stem cells or bone marrow.

The high-dose chemotherapy treatments are given to eliminate the cancer in your body. The infusion of your new marrow through a bone marrow transplant or peripheral stem cells replaces the bone marrow destroyed by the chemotherapy and/or radiation therapy.You may be a potential candidate for an autologous bone marrow transplant if you have lymphoma, multiple myeloma, Hodgkin's disease, germ cell cancer, breast cancer or certain types of leukemia.

Bone marrow transplant procedure in India

Bone marrow transplant procedure in India comprises two major activities: the harvesting of the stem cells and the transplantation of the stem cells.

The procedure for harvesting stem cells is the same for both autologous and allogenic bone marrow transplants in India. Under general anaesthesia, bone marrow is extracted from major bone structure is such as the hip and the spine. There are no surgical incisions, just skin punctures to insert the needles. The harvested stem cells may need to be processed to make them fit for transplantation.

 In the second phase, the actual transplantation procedure is performed. All hospitals that perform bone marrow transplant procedure in India have a special and segregated bone marrow transplant unit which is highly sterile. This is because bone marrow transplant patients are susceptible to infections on account of lower levels of immunity.

Prior to the procedure, catheters are inserted to allow administration of drugs, nutrition etc. Patients would receive medications such as antibiotics and antivirus to prevent as well as to treat infections of any kind. Patients scheduled for allogenic transplant will also receive special medications to prevent rejection of the donor cells by the patients immune system.

Healthy stem cells are introduced into the body through the bloodstream, and no surgery is normally necessary. The stem cells upon reaching the bone marrow, engraft there and after a couple of weeks commence production of normal blood cells.

For more information visit:          http://www.medworldindia.com       
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Please scan and email your medical reports  to us at care@medworldindia.com and we shall get you a Free Medical Opinion from India’s Best Doctors.

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MedWorld India Affiliated Hospitals in India the Leading Destination for Bone Marrow Transplant

Bone Marrow Transplant at World Best Hospitals in India

A large number of foreign patients now come to India for Live Related Organ Transplant Surgery like Kidney Transplants, Liver Transplants and Bone Marrow Transplants. Organ Transplantation is a very complex surgical specialty and requires very high degree of Clinical skills and Medical Technology and Infrastructure. India has now become the most preferred destination for organ transplant procedures. These include Liver, Kidney and Bone marrow transplant surgeries. .Not only the cost is low; the success rate of organ transplant in India is at par with the world's best success rate for organ transplant.

Since Organ Transplantation is a very complex surgical specialty and requires very high degree of Clinical skills and Medical Technology, and Indian surgeons and healthcare has proven its competence, there has been a great surge in the number of medical tourists coming to India for various organ transplants. The Infrastructure and technology used at these best organ transplant hospitals in India is the most sophisticated technology available in the world, which results in better patient recovery, higher success rate, low cost and convenience to the patient.

Bone Marrow Transplant

Stem cells produce red blood cells, white blood cells, and platelets. In some cases, stem cells in your bone marrow may not be functioning well or need to be destroyed to help treat a disease. If this happens, you will need new stem cells.
During this procedure, healthy stem cells are taken from a donor's:

·         Bone marrow (bone marrow transplant or BMT)

·         Blood (peripheral blood stem cell or PBSC)

The stem cells will be injected into your vein. The new cells travel through the bloodstream to your bone cavities. It may take about a month for the donor stem cells in the bone marrow to begin to function fully. If the transplant is successful, new bone marrow cells will produce healthy red blood cells, white blood cells, and platelets.

Stem cell transplantation may be done using:

·         Stem cells that were taken from your own bone marrow or blood and stored

·         Stem cells from a donor

How Bone Marrow Transplant would be done... 

Prior to procedure the donor will be carefully tested to check for diseases. Both you and the donor will be tested to ensure that your tissues are compatible. In order for the transplant to be successful, certain markers, called HLS types, on the blood cells and bone marrow cells must match.

As the recipient, you will be given medicines to suppress your immune system. This is to prevent your body from rejecting the donor stem cells. In the weeks prior to the transplant, you may have to have:

·         Chemotherapy

·         Radiation therapy

This process is called "conditioning." It will rid the body of diseased cells and clear the bone marrow cavities for the new bone marrow.

If the stem cells will be from the donor's bone marrow (BMT), the       doctor will clean an area of the donor's hip. A hollow needle and     syringe will be used to remove the bone marrow.The doctor will make several small punctures. This is to harvest enough bone marrow for the transplant (1-2 quarts). Lastly, the wounds will be covered with bandages.
If the stem cells will be from the donor's blood (PBSC), the doctor will stick a needle in the donor's large vein or veins in the arms. A machine will receive blood from the vein. This machine will spin the blood so that the stem cells are concentrated. The rest of the blood will be given back to the donor. The doctor will cover the puncture wounds with bandages. This procedure may require more than one blood donation. The donor may also be required to take pills that cause more stem cells from the bone marrow to go into the blood.

The donated stem cells will be filtered. Next, the doctor will administer the cells through a small, flexible tube, called a catheter, into one of your large veins.

Immediately after procedure the donor will recover quickly. You, the recipient, will be placed in isolation. This is to avoid infection until the new stem cells in the bone marrow begin to produce infection-fighting cells.

Recovery

The new bone marrow normally takes almost a year in order to function normally. During this period the patient is to be monitored closely to identify any infections or complications that may develop. The recovery process continues for several months or longer after discharging from the hospital, during which time the patient cannot return to work or many previously enjoyed activities.

MedWorld India Affiliated Hospitals in India the Leading Destination for Organ Transplant Surgery

·         Indian doctors are known all over the world for their skill and knowledge and have the experience of studying and working at the best hospitals in the world.

·         India's leading liver transplant centre conducts perhaps the world's highest number of liver transplants (16 to 18 every month).

·         The hospital has a special centre for liver diseases amongst children and liver transplants for children . Highly skilled surgical teams with vast experience and excellent track record of doing largest numbers of Live related donor kidney and liver transplants with survival rates comparable to world's best centers.

·         Most advanced Technology Infrastructure - Blood Bank with 24 hour apharesis facility, advanced laboratory and microbiology (infection control) support, advanced cardiology, DSA and interventionalradiology, portable and colour ultra-sonology, Liver Fibro-scan, 64 slice CT scanner, 3 T MRI, PET-CT and nephrology (including 24 hour dialysis and CVVHD) facilities. Organ Transplant Hospitals in India are now equipped with the latest and high end technology.

For more information visit:          http://www.medworldindia.com      
                    https://www.facebook.com/medworld.india

Please scan and email your medical reports  to us at care@medworldindia.com and we shall get you a Free Medical Opinion from India’s Best Doctors.

Call Us : +91-9811058159

Mail Us : care@medworldindia.com

Leukemia symptoms - Cancer Treatment Centers of India

Cancer can form in and attack any organ or organic system in the human body. When it comes down to blood cancer, it is found that cancerous cells multiply rapidly and violently attack different parts of the circulatory system, making it one of the, if not the most dangerous cancer that could possibly attack anyone. Apart from blood and the lymphatic system; bone marrow is prone to be affected by this kind of cancer.

There are three basic types of blood cancer, primarily. These are:

Leukemia – Because of the rapid increase of cancerous cells that are either affecting the marrow or the blood, the circulatory system loses its ability to produce and regulate blood effectively, hence severely impairing it.

Lymphoma – The cancer affecting lymphocytes is called lymphoma. Lymphocytes are one of the types of white blood corpuscles.

Myeloma – Myeloma affects plasma, another type of white blood corpuscles.

Treating blood cancer is determined by various factors, such as age, how fast the cancer is progressing, where the cancer has spread to, other health conditions, etc.

Leukemia(Blood Cancer) Treatment at BestHospital in India

Leukemia is not a single disease. Instead, the term leukemia refers to a number of related cancers that start in the blood-forming cells of the bone marrow. There are both acute and chronic forms of leukemia, each with many subtypes that vary in their response to treatment. In addition, children with leukemia have special needs that are best met by care in pediatric cancer centers. 

In general, there are five major approaches to the treatment of leukemia:

• Chemotherapy to kill leukemia cells using strong anti-cancer drugs
• Interferon therapy to slow the reproduction of leukemia cells and promote the immune system's anti-leukemia activity
• Radiation therapy to kill cancer cells by exposure to high-energy radiation
• Stem cell transplantation (SCT) to enable treatment with high doses of chemotherapy and radiation therapy and
• Surgery to remove an enlarged spleen or to install a venous access device (large plastic tube) to give medications and withdraw blood samples.

Stem cell transplantation

Younger patients that are at high risk for dying from CLL might consider hematopoietic stem cell transplantation (HSCT). Autologous stem cell transplantation, a lower-risk form of treatment using the patient's own blood cells, is not curative. Myeloablative (bone marrow killing) forms of allogeneic stem cell transplantation, a high-risk treatment using blood cells from a healthy donor, may be curative for some patients, but most patients cannot tolerate the treatment. An intermediate level, called reduced-intensity conditioning allogeneic stem cell transplantation, may be better tolerated by older or frail patients.

Biological Therapy : Biological therapy, also referred to as immunotherapy, involves the treatment with those substances that affect the ability of an immune system to kill cancer cells. Monoclonal antibodies and interferon are the two types of biological therapy. The purpose of monoclonal antibodies is to stick to cancer cells in order to draw the attention of the immune system to these cancer cells. On the other hand, interferon helps in stimulating the immune system so as to destroy the cancer cells. These two options are generally used for chronic leukemia instead of acute leukemia.

Radiotherapy : Radiotherapy, also known as radiation therapy, makes use of energy rays such as X-rays for stopping the growth and multiplication of the cancer cells. This energy is directed at any particular part of the body such as the spleen or also to the entire body.

For more information visit:          http://www.medworldindia.com       
                    https://www.facebook.com/medworld.india

Please scan and email your medical reports  to us at care@medworldindia.com and we shall get you a Free Medical Opinion from India’s Best Doctors.

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Low Cost Bone Marrow Transplant (BMT) in India - All about Bone Marrow Transplant (BMT)

BoneMarrow Transplant (BMT)

A Bone Marrow Transplant is a non surgical procedure in which damaged or diseased bone marrow is replaced with healthy bone marrow stem cells. This complex procedure is performed at many of India's leading hospitals. The success rate for bone marrow transplants in India is on par with international benchmarks.

A bone marrow transplant is usually offered as a solution for certain kinds of cancers as well as some diseases which affect the production of blood cells. Hospitals which perform bone marrow transplants in India have the requisite infrastructure as well as highly experienced haematologists and haemaeto-oncologists to perform the procedure successfully. 

BMT is generally performed in the following cases

• Certain cancers, such as leukaemia, lymphoma, and multiple myeloma
• In case of illnesses such as sickle cell anemia, aplastic anemia, Thalessemia, Congenital Neutropenia etc.
• In case of destruction of the cells due to Chemotherapy or Radiation.

Types of Bone Marrow Transplants

1. Autologus BMT- Patient's own cells are taken and put back again in order to protect the cells from being destroyed by chemotherapy or radiation.
2. Allogenic BMT- The cells of the patient are replaced with the cells of other person called Donor after doing blood matching.
3. Umbilical Cord BMT- In this case the stem cells from umbilical cord is used for the transplantation. These cells are preserved from the time of birth of the patient.

 BMT Procedure

The first step in BMT is the harvesting of bone marrow from the donor. The procedure of harvesting involves the extraction of sufficient amount of bone marrow cells from the donor by making few punctures using a special needle or syringe. Harvesting is done under general anaesthesia and discomfort is usually minimal afterwards. Bone marrow is drawn from the iliac crest (the part of the hip bone to either side of the lower back) .The donor remains at the hospital for 24-48 hours and can resume normal activities within a few days.

 If the bone marrow is meant for an autologous transplant then it is stored at very low temperature and it is used when required. The bone marrow is administered to the recipient via a catheter (a narrow, flexible tube) inserted into a large vein in the chest. From the bloodstream, it migrates to the cavities within the bones where bone marrow is normally stored. If the transplant is successful, the bone marrow begins to produce normal blood cells once it is in place, or engrafted.

Associated Risks
There are risks associated with Bone Marrow Transplant and the level of risk involved depends on various factors such as age, donor matching, type of transplant, treatment, general health, disease etc. Before considering BMT procedure for a patient , tor doctors thoroughly analyze these risk factors.

 Moreover they help the patient to face the rigour of the Transplant procedure. The patient may have to face complications such as bleeding , anemia, nausea, diarrhea, vomiting, cataract graft failure etc.

For more information visit:          http://www.medworldindia.com        
                    https://www.facebook.com/medworld.india

Please scan and email your medical reports  to us at care@medworldindia.com and we shall get you a Free Medical Opinion from India’s Best Doctors.

Call Us : +91-9811058159

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